New Podcast Episode. Aging, Stem Cells, and Biological Clocks
In this episode of The Stem Cell Report, Martin Pera is joined by Konrad Hochedlinger, PhD, and Rebecca Gorelov, PhD, to discuss their recent publication in Stem Cell Reports. Epigenetic clocks are promising biomarkers of aging, but little is known about their cellular basis.
Listen to learn more about how the researchers analyzed immature and mature cell populations from muscle, blood, and a variety of epithelia using three different epigenetic clocks widely used in the field to better interpret existing clocks and improve the development of more sensitive accurate ones.
Guests
Konrad Hochedlinger is a Professor of Medicine and Genetics in the Department of Molecular Biology and the and Gerald and Darlene Jordan Endowed Chair in the Center for Regenerative Medicine at the Massachusetts General Hospital. He also has an appointment in the Harvard Stem Cell Institute. Konrad has received numerous awards over the years including the Howard Hughes Medical Institute Early Career Scientist Award, the Vilcek Prize for Creative Promise in Biomedical Science, and the ISSCR Outstanding Young Investigator Award. Konrad was also a recent member of the ISSCR Board of Directors.
Rebecca Gorelov received her PhD in Biomedical Sciences from Harvard Medical School and did her research in the Hochedlinger laboratory. She is currently an associate at Bain Capital Life Sciences.
Our guests and their colleagues authored the recently published paper, Dissecting the impact of differentiation stage, replicative history, and cell type composition in epigenetic clocks.