The guests on this episode of The Stem Cell Report studied functional variation in human PSC lines as they progress through neurectoderm versus mesendoderm lineages and fore- versus hind-brain development. They will discuss the origin and consequences of inter-individual variation in the early events orchestrating human neural development, the extent to which such variation might impact on adult health and disease, and how it might be exploited in stem cell therapy. 

In this episode of The Stem Cell Report, Martin Pera is joined by Konrad Hochedlinger, PhD, and Rebecca Gorelov, PhD, to discuss their recent publication in Stem Cell Reports. Epigenetic clocks are promising biomarkers of aging, but little is known about their cellular basis.

In this episode of The Stem Cell Report, our guests review the use of models of neurodevelopment to understand neuropsychiatric diseases, focusing on Alzheimer’s and Parkinson’s disease, epilepsy, Down syndrome, and schizophrenia and provide critical appraisal of the impact of human-rodent xenografting approaches for advancing our understanding of those diseases and brain development.